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3 The importance of the gut microbiome in relation to drug response is now widely recognized, and orally administrated herbs and drugs can affect the microbiota and produce metabolites that are different from those generated by the host, and which possess novel features and bioactivities

*Correspondence: Chih-Yuan Ko, [email protected] ORCID: Qiao-Wen Chen, orcid.org/0009-0008-5135-2627

Next, we explored how metformin regulated GLP-1R level and PKA signalling

Statements Author contributions YfM and YqM: writing review and editing

Bioenergetic Prerequisites for Activity-Dependent Neuroplasticity Cell-based interventions may create the metabolic conditions required for neuroplasticity

People taking placebo in the study (not on medicine) lost an average of ~2.5% body weight (or about 6 lb)